Sirt6tm2.2Cxd
Targeted Allele Detail
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| Symbol: |
Sirt6tm2.2Cxd |
| Name: |
sirtuin 6; targeted mutation 2.2, Chu-Xia Deng |
| MGI ID: |
MGI:4867398 |
| Synonyms: |
Sirt6delta2-3 |
| Gene: |
Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
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| Alliance: |
Sirt6tm2.2Cxd page
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Small body size of Sirt6tm2.2Cxd/Sirt6tm2.2Cxd mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:167023
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3. Cre mediated recombination removed exons 2, exon 3, and the neo cassette. The absence of protein expression was confirmed by western blot analysis.
(J:167023)
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Generation of the Sirt6tm2.1Cxd and Sirt6tm2.2Cxd alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Sirt6 Mutation: |
39 strains or lines available
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| Original: |
J:167023 Xiao C, et al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem. 2010 Nov 19;285(47):36776-84 |
| All: |
3 reference(s) |
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Analysis Tools
