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Ighg1tm4Cgn
Targeted Allele Detail
Summary
Symbol: Ighg1tm4Cgn
Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 4, University of Cologne
MGI ID: MGI:4850023
Synonyms: Ighs-hMT
Gene: Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance: Ighg1tm4Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166887
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.7 kb sequence directly upstream of the IgG1 switch region and containing all known IL-4 inducible elements in this region was replaced with a neomycin selection cassette in reverse orientation and the human metallothionein II promoter. The splice donor site of the I exon was retained. (J:166887)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:  28 strains or lines available
Notes
The ES cells targeted to create this allele were heterozygous for Ighg1.
References
Original:  J:166887 Lorenz M, et al., Switch transcripts in immunoglobulin class switching. Science. 1995 Mar 24;267(5205):1825-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory