Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol: Chst15tm1Oh Name: carbohydrate sulfotransferase 15; targeted mutation 1, Osami Habuchi MGI ID: MGI:4840254 Synonyms: Galnac4s-6st- Gene: Chst15  Location: Chr7:131837509-131918957 bp, - strand  Genetic Position: Chr7, 76.29 cM, cytoband F4 Alliance: Chst15tm1Oh page

Abnormal morphology of Chst15tm1Oh/Chst15tm1Oh bone marrow-derived mast cells Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:165927
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 which contains the 3'-phosphoadenosine 5'-phosphosulfate binding site critical for sulfotransferase activity was replaced with a PGK-neomycin selection cassette. RT-Pcr of spleen RNA demonstrated the absence of expression. (J:165927)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Chst15 Mutation:	24 strains or lines available

Original:	J:165927 Ohtake-Niimi S, et al., Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells. J Biol Chem. 2010 Jul 2;285(27):20793-805
All:	2 reference(s)