Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnh3tm1.2Tije
Name:	potassium voltage-gated channel, subfamily H (eag-related), member 3; targeted mutation 1.2, Timothy Jegla
MGI ID:	MGI:4837120
Gene:	Kcnh3  Location: Chr15:99122742-99140698 bp, + strand  Genetic Position: Chr15, 56.08 cM, cytoband F3
Alliance:	Kcnh3tm1.2Tije page

Germline Transmission:	Earliest citation of germline transmission: J:165296
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated recombination Kcnh3tm1.1Tije removed exons 2 through 4. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:165296)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnh3 Mutation:	42 strains or lines available

Original:	J:165296 Zhang X, et al., Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep;13(9):1056-8
All:	1 reference(s)