Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plp1tm1Gow
Name:	proteolipid protein (myelin) 1; targeted mutation 1, Alexander Gow
MGI ID:	MGI:4835262
Synonyms:	Plp neo
Gene:	Plp1  Location: ChrX:135723420-135740482 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Alliance:	Plp1tm1Gow page

Germline Transmission:	Earliest citation of germline transmission: J:62287
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: The splice donor site at the 3' end of exon 3 was inactivated by site directed mutagenesis. A floxed PGKneo selection cassette was then inserted at position 49 of intron 3. Presence of the floxed neo prevents protein expression. (J:62287)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:	19 strains or lines available

Original:	J:62287 Stecca B, et al., The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. J Neurosci. 2000 Jun 1;20(11):4002-10
All:	1 reference(s)