Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Tbx2tm2.2Vmc Name: T-box 2; targeted mutation 2.2, Vincent M Christoffels MGI ID: MGI:4822020 Synonyms: Tbx2delta2 Gene: Tbx2  Location: Chr11:85723441-85732774 bp, + strand  Genetic Position: Chr11, 51.34 cM Alliance: Tbx2tm2.2Vmc page

Tbx2tm2.2Vmc/Tbx2tm2.2Vmc embryo shows duplication of digit IV on both hindlimbs Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:163063
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A FRT flanked neo cassette with a 5' loxP site was inserted within intron 1 and an additional loxP site was inserted within intron 2 by homologous recombination. The selection cassette and exon 2 were removed by flpe and cre mediated recombination. Deletion of Exon 2 is expected to cause the loss of the domain essential for DNA binding and protein interactions and introduces a frame shift resulting in two stop codons in Exon 3 and early termination of translation. (J:163063)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	243 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx2 Mutation:	27 strains or lines available

Original:	J:163063 Wakker V, et al., Generation of mice with a conditional null allele for Tbx2. Genesis. 2010 Mar;48(3):195-9
All:	6 reference(s)