Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itga5tm2.1Hyn
Name:	integrin alpha 5 (fibronectin receptor alpha); targeted mutation 2.1, Richard Hynes
MGI ID:	MGI:4818933
Gene:	Itga5  Location: Chr15:103252713-103275190 bp, - strand  Genetic Position: Chr15, 58.9 cM
Alliance:	Itga5tm2.1Hyn page

Germline Transmission:	Earliest citation of germline transmission: J:161850
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A FRT-flanked Neo cassette and exon 1 were floxed by homologous recombination. The Neo cassette and exon 1 were removed by flp- and cre- mediate recombination respectively. (J:161850)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga5 Mutation:	45 strains or lines available

Original:	J:161850 van der Flier A, et al., Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development. 2010 Jul;137(14):2439-49
All:	1 reference(s)