Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	As3mttm1Djth
Name:	arsenite methyltransferase; targeted mutation 1, David Thomas
MGI ID:	MGI:4818883
Gene:	As3mt  Location: Chr19:46695897-46729538 bp, + strand  Genetic Position: Chr19, 38.97 cM, cytoband D1
Alliance:	As3mttm1Djth page

Germline Transmission:	Earliest citation of germline transmission: J:162148
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo gene replaced exons 3 and 4 and possibly part of 5 by homologous recombination. The knock-out was confirmed by western blotting of liver lysates. (J:162148)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any As3mt Mutation:	22 strains or lines available

Original:	J:162148 Drobna Z, et al., Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. Chem Res Toxicol. 2009 Oct;22(10):1713-20
All:	6 reference(s)