Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sgms2tm1Jia
Name:	sphingomyelin synthase 2; targeted mutation 1, Xian-Cheng Jiang
MGI ID:	MGI:4818459
Synonyms:	SMS2-
Gene:	Sgms2  Location: Chr3:131112634-131197172 bp, - strand  Genetic Position: Chr3, 60.91 cM
Alliance:	Sgms2tm1Jia page

Germline Transmission:	Earliest citation of germline transmission: J:162226
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 90% of exon 2 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on macrophage extracts. (J:162226)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgms2 Mutation:	23 strains or lines available

Original:	J:162226 Hailemariam TK, et al., Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1519-26
All:	16 reference(s)