Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrna1tm1Klee
Name:	cholinergic receptor nicotinic alpha 1 subunit; targeted mutation 1, Kuo-Fen Lee
MGI ID:	MGI:4462390
Synonyms:	AChRalpha1-
Gene:	Chrna1  Location: Chr2:73393625-73410682 bp, - strand  Genetic Position: Chr2, 43.76 cM
Alliance:	Chrna1tm1Klee page

Germline Transmission:	Earliest citation of germline transmission: J:161300
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on hindlimb muscle. (J:161300)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrna1 Mutation:	17 strains or lines available

Original:	J:161300 An MC, et al., Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7
All:	3 reference(s)