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Chtf18tm1.1KhK
Targeted Allele Detail
Summary
Symbol: Chtf18tm1.1KhK
Name: CTF18, chromosome transmission fidelity factor 18; targeted mutation 1.1, Klaus H Kaestner
MGI ID: MGI:4462054
Gene: Chtf18  Location: Chr17:25938004-25946409 bp, - strand  Genetic Position: Chr17, 12.83 cM
Alliance: Chtf18tm1.1KhK page
Small testes in Chtf18tm1.1KhK/Chtf18tm1.1KhK mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161921
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 7. An additional loxP site was inserted downsteam of exon 10. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 7 through 10. Western blot analysis confirmed the absence of protein expression in the testis. (J:194119)
Generation of the Chtf18tm1.1KhK allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chtf18 Mutation:  34 strains or lines available
References
Original:  J:161921 Berkowitz KM, et al., Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. Mol Hum Reprod. 2008 Mar;14(3):143-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory