Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Hsp90b1tm1.2Alee Name: heat shock protein 90, beta (Grp94), member 1; targeted mutation 1.2, Amy Lee MGI ID: MGI:4460991 Synonyms: Grp94- Gene: Hsp90b1  Location: Chr10:86526705-86541308 bp, - strand  Genetic Position: Chr10, 43.05 cM Alliance: Hsp90b1tm1.2Alee page

Embryonic lethality in Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee embryos Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:160900
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed and FRT flanked neomycin cassette was inserted in intron 1 and a third loxP site was inserted in intron 2. The neomycin cassette and exon 2 were subsequently removed by cre recombinase. (J:160900)

Generation of the Hsp90b1tm1.1Alee and Hsp90b1tm1.2Alee alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsp90b1 Mutation:	34 strains or lines available

Original:	J:160900 Mao C, et al., Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One. 2010;5(5):e10852
All:	1 reference(s)