Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Msh2tm2.2Rak
Name:	mutS homolog 2; targeted mutation 2.2, Raju Kucherlapati
MGI ID:	MGI:4460263
Synonyms:	ECMsh2LoxP, Msh2delta12
Gene:	Msh2  Location: Chr17:87979960-88031141 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance:	Msh2tm2.2Rak page

Germline Transmission:	Earliest citation of germline transmission: J:161577
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated recombination removed exon 12 from Msh2tm2.1. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:161577)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:	95 strains or lines available

Original:	J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
All:	3 reference(s)