Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trim3tm1Mak
Name:	tripartite motif-containing 3; targeted mutation 1, Tak Mak
MGI ID:	MGI:4459821
Gene:	Trim3  Location: Chr7:105253670-105282778 bp, - strand  Genetic Position: Chr7, 55.91 cM
Alliance:	Trim3tm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:161372
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of coding exons 2-5 were replaced with a neomycin resistance cassette by homologous recombination. Absence of protein was confirmed by western blot of protein lysates from the brain. (J:161372)

Generation of the Trim3tm1Mak allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trim3 Mutation:	37 strains or lines available

Original:	J:161372 Cheung CC, et al., Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABAA receptors. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11883-8
All:	1 reference(s)