Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Dact1tm1Yegc Name: dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1, Ye-Guang Chen MGI ID: MGI:4458394 Gene: Dact1  Location: Chr12:71356658-71366881 bp, + strand  Genetic Position: Chr12, 29.39 cM Alliance: Dact1tm1Yegc page

Urogenital defects and posterior malformation with a shorter notochord and vertebrae defects in Dact1tm1Yegc/Dact1tm1Yegc mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:161177
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette replaces exon 1 and some flanking sequence. The absence of transcript expression was confirmed by whole mount in situ hybridization on embryos. (J:161177)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

22 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dact1 Mutation:	21 strains or lines available

Original:	J:161177 Wen J, et al., Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem. 2010 Apr 2;285(14):11023-30
All:	2 reference(s)