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Lmnatm6Lgf
Targeted Allele Detail
Summary
Symbol: Lmnatm6Lgf
Name: lamin A; targeted mutation 6, Loren G Fong
MGI ID: MGI:4457608
Synonyms: LmnaPLAO
Gene: Lmna  Location: Chr3:88388455-88413842 bp, - strand  Genetic Position: Chr3, 38.84 cM
Alliance: Lmnatm6Lgf page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsIntrons 10 and 11 of Lmna were deleted thereby abolishing production of lamin C and producing only prelamin A. (J:160705)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  82 strains or lines available
References
Original:  J:160705 Davies BS, et al., An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet. 2010 Jul 1;19(13):2682-94
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory