Tmprss6tm1Dgen
Targeted Allele Detail
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Symbol: |
Tmprss6tm1Dgen |
Name: |
transmembrane serine protease 6; targeted mutation 1, Deltagene |
MGI ID: |
MGI:4457116 |
Synonyms: |
Tmprss6- |
Gene: |
Tmprss6 Location: Chr15:78323867-78352834 bp, - strand Genetic Position: Chr15, 37.49 cM, cytoband E2
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Alliance: |
Tmprss6tm1Dgen page
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Germline Transmission: |
Earliest citation of germline transmission:
J:160248
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Project Collection: |
Deltagen
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The genomic sequence spanning the 3' portion of exon 16 to the 5' portion of exon 17 was replaced. This deletion removed 74 amino acids of the protease domain. This allele is expected to produce a protein lacking protease activity. Reduced expression of a transcript lacking the targeted region was confirmed by QRT-PCR.
(J:160248)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tmprss6 Mutation: |
46 strains or lines available
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Original: |
J:160248 Finberg KE, et al., Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood. 2010 May 6;115(18):3817-26 |
All: |
5 reference(s) |
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