Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdcd1lg2tm4Shr
Name:	programmed cell death 1 ligand 2; targeted mutation 4, Arlene H Sharpe
MGI ID:	MGI:4456974
Synonyms:	PDL1/L2
Gene:	Pdcd1lg2  Location: Chr19:29388319-29448561 bp, + strand  Genetic Position: Chr19, 23.93 cM, cytoband C2-C3
Alliance:	Pdcd1lg2tm4Shr page

Germline Transmission:	Earliest citation of germline transmission: J:160970
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was designed to replace the the IgV exon with a hygromycin resistance gene in ES cells containing the Cd274tm2Shr allele in which the CD274 antigen signal and two-thirds of the IgV exon were replaced with a neomycin cassette. (J:160970)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdcd1lg2 Mutation:	23 strains or lines available

Original:	J:160970 Sharpe A, Generation of PD-L1/PD-L2 mutant. MGI Direct Data Submission. 2010;
All:	3 reference(s)