Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Appl1tm1.2Test
Name:	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; targeted mutation 1.2, Joseph Testa
MGI ID:	MGI:4454678
Gene:	Appl1  Location: Chr14:26640943-26692567 bp, - strand  Genetic Position: Chr14, 16.09 cM, cytoband B
Alliance:	Appl1tm1.2Test page

Germline Transmission:	Earliest citation of germline transmission: J:159889
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated recombination removed exon 5. This allele also lacks the neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:159889)

Generation of the Appl1tm1.1Test and Appl1tm1.2Test alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

56 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Appl1 Mutation:	45 strains or lines available

Original:	J:159889 Tan Y, et al., Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem. 2010 Feb 26;285(9):6377-89
All:	3 reference(s)