Cldn16tm1.1Dmu
Targeted Allele Detail
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Symbol: |
Cldn16tm1.1Dmu |
Name: |
claudin 16; targeted mutation 1.1, Dominik Muller |
MGI ID: |
MGI:4453303 |
Synonyms: |
Cldn16- |
Gene: |
Cldn16 Location: Chr16:26281885-26301515 bp, + strand Genetic Position: Chr16, 18.1 cM, cytoband B2
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Alliance: |
Cldn16tm1.1Dmu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:159706
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT/loxP-flanked pgk-neo cassette and an additional loxP sequence were inserted to flank exon 2, which allowed subsequent deletion of the exon as well as the neomycin resistance cassette. Elimination of exon 2 leads to a frameshift and early stop codon and truncation of the protein. The deletion of exon 2 as well as the neomycin resistance gene was accomplished via Cre-mediated recombination. Western blot analysis showed the absence of protein expression in kidney tissue from homozygous mice.
(J:159706)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cldn16 Mutation: |
14 strains or lines available
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Original: |
J:159706 Will C, et al., Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol. 2010 May;298(5):F1152-61 |
All: |
2 reference(s) |
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