Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Atat1tm1(KOMP)Vlcg Name: alpha tubulin acetyltransferase 1; targeted mutation 1, Velocigene MGI ID: MGI:4453011 Synonyms: alphaTAT1- Gene: Atat1  Location: Chr17:36208487-36220967 bp, - strand  Genetic Position: Chr17, 18.75 cM, cytoband B3 Alliance: Atat1tm1(KOMP)Vlcg page IMPC: Atat1 gene page

Dilated lateral ventricles and abnormal dentate gyrus morphology in Atat1tm1(KOMP)Vlcg/Atat1tm1(KOMP)Vlcg brains Show the 2 phenotype image(s) involving this allele.

Mutant Cell Lines:	14032A-B5, 14032A-C2, 14032A-D10
Germline Transmission:	Earliest citation of germline transmission: J:201922
Parent Cell Line:	VGB6 (ES Cell)
Strain of Origin:	C57BL/6NTac
Project Collection:	KOMP-Regeneron

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1   Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 9210bp between positions 36211715-36220924 of Chromosome 17 (Build GRCm39). The lacZ and floxed neomycin resistance cassette replaced all the coding exons. RT-PCR confirmed the absence of transcript expression in the testis, kidney, liver, lung, adrenal gland, prostate, spleen, small intestine, fat, pancreas, brain and heart. (J:136110, J:201922)

Strategy for the generation of the Atat1tm1(KOMP)Vlcg allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	57 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Atat1 Mutation:	28 strains or lines available

Original:	J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:	7 reference(s)