Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cldn2tm1Muto
Name:	claudin 2; targeted mutation 1, Shigeaki Muto
MGI ID:	MGI:4452519
Synonyms:	Cldn2-
Gene:	Cldn2  Location: ChrX:138701577-138712135 bp, + strand  Genetic Position: ChrX, 61.35 cM
Alliance:	Cldn2tm1Muto page

Germline Transmission:	Earliest citation of germline transmission: J:159379
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding sequence for 1 to 111 amino acids of the single exon was replaced with a neomycin resistance gene. (J:159379)

Generation of the Cldn2tm1Muto allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cldn2 Mutation:	9 strains or lines available

Original:	J:159379 Muto S, et al., Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):8011-6
All:	6 reference(s)