Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ces1dtm1Reli
Name:	carboxylesterase 1D; targeted mutation 1, Richard Lehner
MGI ID:	MGI:4440967
Synonyms:	Ces1dtm1Rile, Tgh-
Gene:	Ces1d  Location: Chr8:93892700-93924432 bp, - strand  Genetic Position: Chr8, 45.05 cM, cytoband C5
Alliance:	Ces1dtm1Reli page

Germline Transmission:	Earliest citation of germline transmission: J:158743
Parent Cell Line:	iTL1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5, which encodes the catalytic serine at position 221, was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:158743)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ces1d Mutation:	40 strains or lines available

Original:	J:158743 Wei E, et al., Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure. Cell Metab. 2010 Mar 3;11(3):183-93
All:	6 reference(s)