Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gria4tm2.1Rlh
Name:	glutamate receptor, ionotropic, AMPA4 (alpha 4); targeted mutation 2.1, Richard L Huganir
MGI ID:	MGI:4437563
Synonyms:	GluR4 delta 7
Gene:	Gria4  Location: Chr9:4417896-4796234 bp, - strand  Genetic Position: Chr9, 2.46 cM
Alliance:	Gria4tm2.1Rlh page

Germline Transmission:	Earliest citation of germline transmission: J:183900
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP-flanked neomycin cassette was inserted into the intron right before the exon encoding the C-terminus region of the targeted gene. An artificial stop codon plus an additional AatII restriction enzyme site were introduced by PCR mutagenesis so as to eliminate the last seven amino acids from the translated protein. The neomycin resistance cassette was excised in the germline by Cre recombinase. (J:183900)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria4 Mutation:	72 strains or lines available

Original:	J:183900 Huganir RL, Direct Data Submission 2010-03-18. MGI Direct Data Submission. 2012;
All:	1 reference(s)