Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ripk3tm1Xidw
Name:	receptor-interacting serine-threonine kinase 3; targeted mutation 1, Xiaodong Wang
MGI ID:	MGI:4431195
Synonyms:	Ripk3-
Gene:	Ripk3  Location: Chr14:56022452-56026314 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Alliance:	Ripk3tm1Xidw page

Germline Transmission:	Earliest citation of germline transmission: J:157346
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 through 3 were replaced with a loxP site flanked neomycin resistance gene cassette. The absence of protein exprerssion was confirmed by western blot analysis on saline- and cerulein-treated mouse embryonic fibroblasts. (J:157346)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ripk3 Mutation:	31 strains or lines available

Original:	J:157346 He S, et al., Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009 Jun 12;137(6):1100-11
All:	31 reference(s)