Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fa2htm1.1Hama
Name:	fatty acid 2-hydroxylase; targeted mutation 1.1, Hiroko Hama
MGI ID:	MGI:4430585
Synonyms:	Fa2h-
Gene:	Fa2h  Location: Chr8:112071770-112120453 bp, - strand  Genetic Position: Chr8, 57.98 cM
Alliance:	Fa2htm1.1Hama page

Germline Transmission:	Earliest citation of germline transmission: J:171655
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted in intron 4 and an FRT flanked neo cassette and loxP site were inserted in intron 6 via homologous recombination. Cre mediated recombination removed exons 5 and 6 and the neo cassette. Homozygous mice express a shorter mRNA form at levels similar to expression of the full length form in wild-type mice. (J:171655)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fa2h Mutation:	23 strains or lines available

Original:	J:171655 Potter KA, et al., Central nervous system dysfunction in a mouse model of Fa2h deficiency. Glia. 2011 Jul;59(7):1009-21
All:	1 reference(s)