Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Stk3tm1.1Yy
Name:	serine/threonine kinase 3; targeted mutation 1.1, Yingzi Yang
MGI ID:	MGI:4422170
Synonyms:	Mst2delta
Gene:	Stk3  Location: Chr15:34875645-35155990 bp, - strand  Genetic Position: Chr15, 14.34 cM, cytoband B3.3
Alliance:	Stk3tm1.1Yy page

Germline Transmission:	Earliest citation of germline transmission: J:156541
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 5 and an frt flanked neo cassette and second loxP site were inserted downstream of exon 6. Cre mediated recombination then removed exons 5 and 6 (encoding the kinase domain) and the neo cassette. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:156541)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Stk3tm1.1Yy

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk3 Mutation:	47 strains or lines available

Original:	J:156541 Song H, et al., Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1431-6
All:	3 reference(s)