Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Phlpp1tm1.1Saco
Name:	PH domain and leucine rich repeat protein phosphatase 1; targeted mutation 1.1, Paolo Sassone-Corsi
MGI ID:	MGI:4421807
Gene:	Phlpp1  Location: Chr1:106099599-106321975 bp, + strand  Genetic Position: Chr1, 49.76 cM
Alliance:	Phlpp1tm1.1Saco page

Germline Transmission:	Earliest citation of germline transmission: J:156530
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was floxed and an frt flanked neo cassette was inserted in intron 4 via homologous recombination. Cre mediated recombination then removed exon 4. RT-PCR and western blot analysis confirmed the absence of RNA and protein expression in brains from homozygous mice. (J:156530)

Generation of the Phlpp1tm1Saco and Phlpp1tm1.1Saco alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phlpp1 Mutation:	52 strains or lines available

Original:	J:156530 Masubuchi S, et al., Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1642-7
All:	20 reference(s)