Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sparctm1Anjm
Name:	secreted acidic cysteine rich glycoprotein; targeted mutation 1, Andrew N J McKenzie
MGI ID:	MGI:4421677
Gene:	Sparc  Location: Chr11:55284985-55310906 bp, - strand  Genetic Position: Chr11, 33.04 cM, cytoband B1
Alliance:	Sparctm1Anjm page

Germline Transmission:	Earliest citation of germline transmission: J:155870
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A lox P site and neo cassette were inserted between exons 5 and 7, eliminating exon 6, as well as inserting stop codons into all three frames upstream of the neo. (J:155870)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sparc Mutation:	75 strains or lines available

Original:	J:155870 Barlow JL, et al., A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010 Jan;16(1):59-66
All:	1 reference(s)