Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Pdctm1Luhe Name: phosducin; targeted mutation 1, Lutz Hein MGI ID: MGI:4417957 Gene: Pdc  Location: Chr1:150195168-150209657 bp, + strand  Genetic Position: Chr1, 63.84 cM Alliance: Pdctm1Luhe page

Increased pupil diameter in Pdctm1Luhe/Pdctm1Luhe mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:155373
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on retinal extracts. (J:155373)

Generation of the Pdctm1Luhe allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdc Mutation:	22 strains or lines available

Original:	J:155373 Beetz N, et al., Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009 Dec;119(12):3597-3612
All:	1 reference(s)