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Plec/Parp10tm1.1Gwi
Targeted Allele Detail
Summary
Symbol: Plec/Parp10tm1.1Gwi
Name: plectin; targeted mutation 1.1, Gerhard Wiche
MGI ID: MGI:4414773
Synonyms: P1c-
Gene: Plec  Location: Chr15:76055174-76115578 bp, - strand  Genetic Position: Chr15, 35.48 cM
Alliance: Plec/Parp10tm1.1Gwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155511
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsExons -1, 0, 0a, and 1c of Plec and exons 10 and 11 of Parp10 were replaced with a floxed neo cassette. The neo cassette was removed by cre mediated recombination. The absence of Plec protein expression of isoform C was confirmed by western blot analysis on brain and sciatic nerve extracts. (J:155511)
Generation of the Plec/Parp10tm1.1Gwi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plec Mutation:  173 strains or lines available
References
Original:  J:155511 Fuchs P, et al., Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity. J Biol Chem. 2009 Sep 25;284(39):26502-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory