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Lrrk2tm1.1Cai
Targeted Allele Detail
Summary
Symbol: Lrrk2tm1.1Cai
Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Huaibin Cai
MGI ID: MGI:4414662
Gene: Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance: Lrrk2tm1.1Cai page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:154755
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 1 and an frt-flanked neo cassette with a second loxP site was inserted into intron 2. Cre mediated recombination removed the neo cassette and exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:154755)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:  156 strains or lines available
References
Original:  J:154755 Parisiadou L, et al., Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci. 2009 Nov 4;29(44):13971-80
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory