About   Help   FAQ
Mtmr14tm1Ckq
Targeted Allele Detail
Summary
Symbol: Mtmr14tm1Ckq
Name: myotubularin related protein 14; targeted mutation 1, Cheng-Kui Qu
MGI ID: MGI:4412297
Synonyms: MIP-, MTMR14-
Gene: Mtmr14  Location: Chr6:113214804-113258353 bp, + strand  Genetic Position: Chr6, 52.74 cM
Alliance: Mtmr14tm1Ckq page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155068
Parent Cell Line:  D1 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 5 were replaced by a neo cassette. The absence of protein expression was confirmed by Western blot analysis on lung, liver, heart, kidney, spleen, and skeletal muscle. (J:155068)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtmr14 Mutation:  38 strains or lines available
References
Original:  J:155068 Shen J, et al., Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol. 2009 Jun;11(6):769-76
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory