Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Steap3tm1.1Atel
Name:	STEAP family member 3; targeted mutation 1.1, Adam Telerman
MGI ID:	MGI:4398911
Synonyms:	TSAP6-, Tsap6del2-3, TSAP6 KO
Gene:	Steap3  Location: Chr1:120154137-120198810 bp, - strand  Genetic Position: Chr1, 52.66 cM, cytoband E2
Alliance:	Steap3tm1.1Atel page

Germline Transmission:	Earliest citation of germline transmission: J:154356
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 46 bp polynucleotide containing a LoxP site was added 404bp upstream exon 2, and a neomycin resistance gene floxed by two LoxP sites was added 533bp downstream exon 3. Cre-mediated excision of exons 2-3 was achieved upon electroporation of a Cre-recombinase expression vector in the correctly targeted ES clones. Protein was undetected in homozygous mutant mice by Western blot analysis and Immnunohistological staining. (J:154356)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Steap3 Mutation:	63 strains or lines available

Original:	J:154356 Lespagnol A, et al., Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008 Nov;15(11):1723-33
All:	1 reference(s)