Pkd1tm2.2Bol
Targeted Allele Detail
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Symbol: |
Pkd1tm2.2Bol |
Name: |
polycystin 1, transient receptor potential channel interacting; targeted mutation 2.2, Alessandra Boletta |
MGI ID: |
MGI:4366013 |
Synonyms: |
Pkd1deltaC, Pkd1deltaCMyc |
Gene: |
Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
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Alliance: |
Pkd1tm2.2Bol page
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Pkd1tm2.2Bol/Pkd1tm2.2Bol embryos show mild hydrocephalus at E16.5
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:153606
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Parent Cell Line: |
TBV2 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Germ line, cre mediated recombination removed the HA tag, exon 45, and exon 46. The truncated protein remains myc-tagged. The expression of the truncated protein lacking the C-terminus was confirmed by western blot analysis.
(J:153606)
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Generation of the Pkd1tm2.1Bol and Pkd1tm2.2Bol alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pkd1 Mutation: |
153 strains or lines available
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Original: |
J:153606 Wodarczyk C, et al., A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137 |
All: |
4 reference(s) |
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