Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm10Asim
Name:	orthodenticle homeobox 2; targeted mutation 10, Antonio Simeone
MGI ID:	MGI:4365829
Synonyms:	Otx2deltaCD
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm10Asim page

Germline Transmission:	Earliest citation of germline transmission: J:153562
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Regions containing the third and fourth transcriptional start sites were deleted and a floxed neo cassette was inserted in the downstream intron. The absence of protein expression of isoforms C and D was confirmed by western blot analysis. (J:153562)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	66 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:153562 Acampora D, et al., Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
All:	1 reference(s)