Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Ehd4tm1.1Haba Name: EH-domain containing 4; targeted mutation 1.1, Hamid Band MGI ID: MGI:4360181 Synonyms: Ehd4- Gene: Ehd4  Location: Chr2:119919958-119985028 bp, - strand  Genetic Position: Chr2, 60.16 cM Alliance: Ehd4tm1.1Haba page

Reduced testicular size in Ehd4tm1.1Haba/Ehd4tm1.1Haba mice Show the 8 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:152735
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Using a series of recombineering reactions, two loxP sites flanking exon 1 were introduced. An FRT-Neo-FRT selection cassette was immediately preceding the second loxP site. Exon 1 and the Neo cassette were deleted upon Cre-mediated recombination. No protein was detected in the lung, kidney, heart, spleen, brain, liver, thymus, or testis of homozygous mice by Western blot. (J:160188)

Generation of the Ehd4tm1.1Haba allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehd4 Mutation:	26 strains or lines available

Original:	J:152735 Sengupta S, et al., EHD4 and CDH23 are interacting partners in cochlear hair cells. J Biol Chem. 2009 Jul 24;284(30):20121-9
All:	4 reference(s)