Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tln2tm2Crit
Name:	talin 2; targeted mutation 2, David R Critchley
MGI ID:	MGI:4358373
Synonyms:	T2BD, T2CD, Talin2 CDS deleted, Tln2cd
Gene:	Tln2  Location: Chr9:67124369-67466985 bp, - strand  Genetic Position: Chr9, 36.39 cM
Alliance:	Tln2tm2Crit page

Germline Transmission:	Earliest citation of germline transmission: J:152372
Parent Cell Line:	E14.1a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was generated by flanking the entire coding sequence (exon1-56) with loxP sites and then deleting them in ES cells. These ES cells were then used to generate mice. Western blot analysis confirmed the absence of protein expression. (J:152372, J:190037)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tln2 Mutation:	149 strains or lines available

Original:	J:152372 Monkley SJ, Targeted alleles of Tln2. MGI Direct Data Submission. 2009;
All:	4 reference(s)