Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tanktm1Aki
Name:	TRAF family member-associated Nf-kappa B activator; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:4355741
Gene:	Tank  Location: Chr2:61408929-61484515 bp, + strand  Genetic Position: Chr2, 35.56 cM
Alliance:	Tanktm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:151757
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The open reading frame encoded in exons 3 and 4 were replaced by a neomycin resistance cassette. Expression of mRNA and protein from the locus was abrogated as determined by Northern and Western analysis on homozygote macrophage extracts. (J:151757)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tank Mutation:	30 strains or lines available

Original:	J:151757 Kawagoe T, et al., TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat Immunol. 2009 Sep;10(9):965-72
All:	7 reference(s)