Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Decr1tm1Jkh Name: 2,4-dienoyl CoA reductase 1, mitochondrial; targeted mutation 1, J Kalervo Hiltunen MGI ID: MGI:4355415 Synonyms: Decr- Gene: Decr1  Location: Chr4:15917240-15945377 bp, - strand  Genetic Position: Chr4, 6.66 cM, cytoband A2 Alliance: Decr1tm1Jkh page

Fasted Decr1tm1Jkh/Decr1tm1Jkh mice show accumulation of lipids in the liver Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:151622
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver, muscle, and heart extracts. (J:151622)

Generation of the Decr1tm1Jkh allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Decr1 Mutation:	25 strains or lines available

Original:	J:151622 Miinalainen IJ, et al., Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. PLoS Genet. 2009 Jul;5(7):e1000543
All:	2 reference(s)