Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grid2tm2Msmh
Name:	glutamate receptor, ionotropic, delta 2; targeted mutation 2, Masayoshi Mishina
MGI ID:	MGI:3851243
Synonyms:	GluRdelta2deltaS
Gene:	Grid2  Location: Chr6:63232860-64681307 bp, + strand  Genetic Position: Chr6, 29.77 cM
Alliance:	Grid2tm2Msmh page

Germline Transmission:	Earliest citation of germline transmission: J:150621
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The Shank-binding segment in exon 16 was removed and an frt-flanked neo cassette was inserted downstream of the modified exon. Reduced protein expression was confirmed by western blot analysis on cerebellar extracts. (J:150621)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grid2 Mutation:	85 strains or lines available

Original:	J:150621 Yasumura M, et al., Role of the internal Shank-binding segment of glutamate receptor delta2 in synaptic localization and cerebellar functions. Neurosci Lett. 2008 Mar 12;433(2):146-51
All:	1 reference(s)