Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Actg1tm1.1Erv Name: actin, gamma, cytoplasmic 1; targeted mutation 1.1, James M Ervasti MGI ID: MGI:3849834 Gene: Actg1  Location: Chr11:120236513-120239321 bp, - strand  Genetic Position: Chr11, 84.07 cM, cytoband E2 Alliance: Actg1tm1.1Erv page

Morphology of stereocilia bundles in adult wild-type and Actg1tm1.1Erv/Actg1tm1.1Erv mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:150067
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre mediated recombination removed exon 2 and 3. The absence of protein product was confirmed by western blot analysis on cochlear, brain, kidney, and lung extracts. (J:112808, J:150067)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actg1 Mutation:	23 strains or lines available

Original:	J:150067 Belyantseva IA, et al., Gamma-actin is required for cytoskeletal maintenance but not development. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9703-8
All:	6 reference(s)