Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fbxo45tm1Kei
Name:	F-box protein 45; targeted mutation 1, Keiichi I Nakayama
MGI ID:	MGI:3849742
Gene:	Fbxo45  Location: Chr16:32048930-32065843 bp, - strand  Genetic Position: Chr16, 22.45 cM
Alliance:	Fbxo45tm1Kei page

Germline Transmission:	Earliest citation of germline transmission: J:149890
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1 kb genomic DNA fragment containing exon 1was replaced with an IRES-lacZ and neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of protein expression in all tissues examined. (J:149890)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxo45 Mutation:	12 strains or lines available

Original:	J:149890 Saiga T, et al., Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43
All:	1 reference(s)