Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Hsf4tm1Xyk Name: heat shock transcription factor 4; targeted mutation 1, Xiangyin Kong MGI ID: MGI:3848361 Gene: Hsf4  Location: Chr8:105996433-106002477 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1 Alliance: Hsf4tm1Xyk page

Lens abnormalities and developmental defects in Hsf4tm1Xyk/Hsf4tm1Xyk mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:149354
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 3-5 were replaced with a PGK-neomycin resistance cassette. (J:149354)

Generation of the Hsf4tm1Xyk allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsf4 Mutation:	30 strains or lines available

Original:	J:149354 Shi X, et al., Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression. BMC Mol Biol. 2009;10:10
All:	2 reference(s)