Col14a1tm1Debi
Targeted Allele Detail
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| Symbol: |
Col14a1tm1Debi |
| Name: |
collagen, type XIV, alpha 1; targeted mutation 1, David E Birk |
| MGI ID: |
MGI:3846440 |
| Gene: |
Col14a1 Location: Chr15:55171146-55384199 bp, + strand Genetic Position: Chr15, 21.96 cM, cytoband D
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| Alliance: |
Col14a1tm1Debi page
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Altered fibroblast and fiber organization in P4 tendons from Col14a1tm1Debi/Col14a1tm1Debi mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:148619
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: A nonsense mutation was generated by inserting a stop codon followed by a neo-TK cassette into exon 4. Immunoblot analysis confirmed the absence of protein expression in the skin of homozygous mice at P12 and P60
(J:148619)
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Creation of the Col14a1tm1Debi allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Col14a1 Mutation: |
80 strains or lines available
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| Original: |
J:148619 Ansorge HL, et al., Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE. J Biol Chem. 2009 Mar 27;284(13):8427-38 |
| All: |
3 reference(s) |
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Analysis Tools
