Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Hmox1tm1.2Gkl Name: heme oxygenase 1; targeted mutation 1.2, George Kollias MGI ID: MGI:3846093 Synonyms: Hmox1D, HO-1KO Gene: Hmox1  Location: Chr8:75820249-75827217 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1 Alliance: Hmox1tm1.2Gkl page

Chronic inflammatory disease in Hmox1tm1.2Gkl/Hmox1tm1.2Gkl mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:148498
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Germ line, cre mediated recombination was used to remove exon 2 through 4. The absence of protein expression was confirmed by western blot analysis on thioglycollate-stimulated peritoneal macrophage. (J:148498)

Generation of Hmox1tm1.1Gkl and Hmox1tm1.2Gkl alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:	33 strains or lines available

Original:	J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
All:	1 reference(s)