Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Htr6tm1Tct
Name:	5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1, Laurence H Tercott
MGI ID:	MGI:3844587
Gene:	Htr6  Location: Chr4:138788419-138802881 bp, - strand  Genetic Position: Chr4, 70.57 cM
Alliance:	Htr6tm1Tct page

Germline Transmission:	Earliest citation of germline transmission: J:148381
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 300 bp fragment of exon 1 was replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of wild-type transcript in brains from homozygous mice. (J:148381)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr6 Mutation:	26 strains or lines available

Original:	J:148381 Bonasera SJ, et al., A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology. 2006 Aug;31(8):1801-13
All:	3 reference(s)