Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc12a1tm2Haca
Name:	solute carrier family 12, member 1; targeted mutation 2, Hayo Castrop
MGI ID:	MGI:3843784
Synonyms:	NKCC2A-
Gene:	Slc12a1  Location: Chr2:124994430-125071922 bp, + strand  Genetic Position: Chr2, 61.23 cM
Alliance:	Slc12a1tm2Haca page

Germline Transmission:	Earliest citation of germline transmission: J:148062
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4A was replaced with a STOP and floxed neo cassette. Germ line, cre mediated recombination was removed the neo cassette. The absence of transcript expression for isoform A was confirmed by real time RT-PCR on kidney extracts. (J:148062)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc12a1 Mutation:	55 strains or lines available

Original:	J:148062 Oppermann M, et al., Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter. J Am Soc Nephrol. 2007 Feb;18(2):440-8
All:	1 reference(s)