Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il27tm1Cua
Name:	interleukin 27; targeted mutation 1, Daniel J Cua
MGI ID:	MGI:3842663
Synonyms:	IL-27p28-
Gene:	Il27  Location: Chr7:126188182-126194113 bp, - strand  Genetic Position: Chr7, 69.18 cM
Alliance:	Il27tm1Cua page

Germline Transmission:	Earliest citation of germline transmission: J:147706
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exons 2 through 5 were replaced with a FRT-flanked neomycin resistance cassette. Gene inactivation was confirmed in homozygote bone marrow derived macrophages and dendritic cells by real-time PCR. (J:147706)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il27 Mutation:	20 strains or lines available

Original:	J:147706 Diveu C, et al., IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol. 2009 May 1;182(9):5748-56
All:	3 reference(s)