Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aqp7tm1Nlsn
Name:	aquaporin 7; targeted mutation 1, Soren Nielsen
MGI ID:	MGI:3841695
Gene:	Aqp7  Location: Chr4:41033074-41048139 bp, - strand  Genetic Position: Chr4, 20.83 cM, cytoband B1
Alliance:	Aqp7tm1Nlsn page

Germline Transmission:	Earliest citation of germline transmission: J:147631
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 41 bp fragment from the middle of exon 5 was replaced with a neo cassette via homologous recombination. Immunoblot and immunohistochemical analysis confirmed the absence of protein expression in white adipose tissue, cardiac and skeletal muscle, testes, and kidneys from homozygous mice. (J:147631)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp7 Mutation:	24 strains or lines available

Original:	J:147631 Skowronski MT, et al., AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism. Am J Physiol Renal Physiol. 2007 Mar;292(3):F956-65
All:	3 reference(s)